A low-protein diet causes an increase in life expectancy through a single hormone: healing practice.

Longer life with less protein

One low protein dietbut still enough protein to avoid malnutrition, improves life expectancy and metabolic health. It has now been determined that a single liver-derived hormone appears to be responsible for these beneficial effects.

Data from a new study involving experts from the Pennington Biomedical Research Center show that protein restriction has marked beneficial effects on lifespan and metabolic health in aged male mice and a single metabolic hormone called FGF21 is essential for the antiaging effects of this dietary behavior.

The results can be read in the English magazine “Nature”.

Too much protein shortens life expectancy

excessive Consumption of foods rich in protein has been in the past with one increased mortality in certain age groups, experts report.

Improve metabolism due to less protein

On the other hand, a restriction of protein intake increasingly recognized among professionals as a unique approach to Improve metabolic health accepted. However, the question arises about the mechanisms by which this positive effect is triggered.

There is growing interest in the possibility of reducing protein or amino acid intake contributes to this positive effect. The new research should help confirm this assumption and identify the responsible sources.

Role of FGF21 in life expectancy

Recent results in mice suggest that Hormonal Fibroblast Growth Factor 21 (FGF21) mediates the metabolic effects of protein restriction in young animals, the team found. FGF21 is a key signal that connects the body to the brain during protein restriction.

If such a signal is missing in young mice that ate a low-protein diet, the animals changed neither their eating behavior nor their metabolism, the researchers report.

Our data suggest that FGF21 communicates with the brain, and without this signal, the mouse does not know that it is eating a low-protein diet. As a result, the mouse cannot adaptively change its metabolism or feeding behavior.‘, explains the author of the study. professor dr christopher morrison in a press release.

Beneficial Effects of Less Protein

it turned out that one low protein diet in aged mice positive effects on metabolism improving metabolic health, reducing frailty and increasing life expectancy.

These beneficial effects were also evident when protein intake was reduced in mice. middle aged was reduced, and even protected against disadvantages of obesityaccording to experts.

FGF21 vital for a longer life

However, since these positive effects, as mentioned above, in mice, FGF21 was absentwere lost, this suggests that the action of FGF21 in the brain may improve the health and life expectancy of crucial importance it is.

We have previously shown that FGF21 acts in the brain to improve metabolic health in young mice fed a low-protein diet. These new data extend this work by showing that FGF21 also improves metabolic health and lengthens life expectancy.‘ reports the author of the study. dr Cerro Cristal M

According to the expert, protein restriction increased life expectancy, reduced frailty, decreased body weight and obesity, and improved exercise capacity, at least in male mice.

Better glucose tolerance through lower protein intake

Other beneficial effects of restricting the amount of protein ingested in the animals were one Increased glucose tolerance and of various metabolic markers in serum, liver and adipose tissue, according to Dr. Colina.

In contrast, mice lacking FGF21 do not show metabolic responses to protein restriction early in life, and later in life show early-onset age-related weight loss, a decreased physical performanceincreased brittleness and reduced life expectancy.

These data show that protein restriction has significant beneficial effects on lifespan and metabolic health in aging male mice, and that a single metabolic hormone, FGF21, is responsible for the anti-aging effect of this action related to nutrition is essential.

FGF21 coordinates metabolic health

Overall, the data is clear evidence that FGF21 first known hormone is that that Coordinated nutritional behavior and metabolic healthto improve life expectancy during protein restriction,” adds Dr. Choline added.

Compensate for health problems in old age caused by FGF21

If scientists can better understand how diet and nutritive hormones like FGF21 extend lifespan, these discoveries could offset many of the health problems that occur in middle and old age.‘ adds the author of the study dr John Kirwan aggregate.

In the future, how these observations in mice can be extrapolated to older humans should be investigated. The results of the new research are expected to uncover new molecular and neural pathways that can further improve people’s health, the team says. (What)

Author and source of information

This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.


  • Diana C Albarado, Lucia G Coco, Redin A Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, et al.: FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice; in Nature: (published on 04/07/2022), Nature
  • Pennington Biomedical Research Center: A Single Hormone Drives the Body’s Responses to Low-Protein Diet (Posted 05/13/2022), Pennington Biomedical Research Center

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.


Leave your vote

Leave a Comment

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.