Formononetin allows the treatment of food allergies
One on plants and herbs like Red clover and green beans active ingredient present allows a effective treatment of food allergies.
In a new study involving researchers from the New York Medical School it was found that formononetin could be a new therapeutic candidate for the treatment and prevention of IgE/mast cell-mediated food allergies and other allergic diseases.
The study results were presented at this year’s American Society for Biochemistry and Molecular Biology meeting.
What is formononetin?
Formononetin is available in different Contains plants and herbs. and has been shown to have anti-cancer properties. Formononetin is one of the so-called phytoestrogen. In other words, formononetin is similar in structure to estrogen and can bind to estrogen receptors in the body.
Does formononetin help with food allergies?
In the research work, advanced calculation methods were combined with experimental studies. The experts wanted to gain new insights at the cellular level into how the plant substance formononetin can be used. Food allergy treatment It can be used.
“Our results show that formononetin is an especially good therapeutic candidate for the treatment of food allergies.‘ reports the author of the study. Ibrahim Musa from the New York Medical School in a press release.
According to the expert, the current study has also shown new mechanisms and points of attack, which are important for the development future medications to treat food allergies and other allergic diseases or for Prevention of severe anaphylaxis It can be used in allergic diseases.
Why do food allergies occur?
If that immune system Viewing a food or even a single component of a food as threatening leads to food allergies.
This is where the immune system begins. Immunoglobulin E (IgE) antibodies to produce. These react to food and cause allergic symptoms such as hives, asthma, itching, difficulty breathing or diarrhea.
Previous research by the same research team had already shown that formononetin could be used as a potential therapeutic for allergies because Formononetin reduces IgE production.
Study included systems pharmacology
In their new study, the experts used an approach that systems pharmacology called for more information on the effects of formononetin.
Data from publicly available databases were used to identify gene and protein targets involved in Food allergies and mast cell diseases be regulated. Mast cells also play an important role in IgE-mediated allergic diseases.
After identifying the gene and protein targets, the experts validated them with cultured cell lines, which are often used in allergy studies. The results of these cell experiments show that formononetin affects the expression of the identified genes and proteins.
Does formononetin also help with other allergies?
“Our study shows that systems pharmacology can be used to predict drug-target protein interactions. Furthermore, the mechanism of action identified for formononetin is also important for other allergic diseases such as allergic asthma and hay fever.‘ reports the author of the study. muse.
Taken together, the results suggest that formononetin or other therapeutic agents capable of reduce IgE productionfor the treatment of the corresponding allergic diseases could be beneficial.
For future research, the team already has a mouse model to peanut allergy was developed with the help of which the effects of formononetin should be examined more closely. In addition, the experts also want to know more about the possible side effects can be triggered by formononetin. (What)
Author and source of information
This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.
- Ibrahim Musa: Computational and mechanistic study of the therapeutic potential of the formononetin compound to prevent mast cell activation and IgE production in alimentary anaphylaxis; American Society for Biochemistry and Molecular Biology (published 4/5/2022), American Society for Biochemistry and Molecular Biology
- Experimental Biology: Plant compound shows promise in alleviating food allergies (Posted 4/1/2022), Experimental Biology
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.