DEBInet Nutrition Blog » Blog Archive Men in particular benefit from a healthy lifestyle

Author: Dr. oec. Christina Bächle, editor: Dr. Bertil Kluthe
© Kluthe Foundation Nutrition and Health

Tuesday, May 31, 2022

According to a recent study by the German Cancer Research Center (DKFZ), men who maintain a healthy lifestyle live up to 17 years longer than their contemporaries with very unhealthy lifestyle habits. Women also benefit from maintaining a healthy lifestyle, although to a lesser extent.

For more than 20 years, the DKFZ has been involved in the EPIC study (European Prospective Investigation into Cancer and Nutrition), a pan-European long-term study to investigate the connection between nutrition, lifestyle factors and cancer. . For the current analysis, the DKFZ scientists used data from the Heidelberg arm of the EPIC study. In and around Heidelberg, more than 25,000 middle-aged to older subjects participated in the EPIC study. During the follow-up period (until 2014), 2,571 of the Heidelberg participants died.

In the course of their evaluations, the scientists created a profile of lifestyle-related risk factors for each participant. Seven factors were taken into account: smoking, BMI, waist circumference, alcohol consumption, physical activity, diabetes and arterial hypertension. The subjects were then divided into groups according to their lifestyle profile. Each of the following comparisons relates to a fifth of the subjects with the most favorable versus unfavorable lifestyle profiles.

Here it was revealed that the life expectancy of men with the most favorable lifestyle was 16.8 years longer than that of men with the least favorable lifestyle. For women, the difference was smaller but still 9.9 years.

In the next step of the analysis, the scientists included five blood biomarkers that indicate different aspects of biological aging. GDF-15 (Growth Differentiation Factor 15) is an indicator of oxidative stress, inflammation, and mitochondrial dysfunction, cystatin C indicates kidney function, and NT-proBNP indicates heart damage. Long-term blood sugar value HbA1c and C-reactive protein (CRP) as a marker of systemic inflammation were also included.

When these biomarkers were also taken into account, the difference in life expectancy widened even more: men with the most favorable values ​​had a life expectancy 22.7 years longer than men with the least favorable values. The difference in study participants was 14 years.

The results can help develop prevention strategies. In addition, they are particularly interesting from the point of view of health education, as the study’s lead author, Dr. Bernard Srour, explains: “Probable loss of life expectancy is a useful and easy-to-understand measure that doctors, for example, can use to motivate their patients to give up unhealthy habits. It could also be used to identify people with particularly high health risks who might benefit from direct interventions.”

written by dr. oec. trophic Christina Bächle on May 31, 2022 at 08:22



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