A ketogenic diet uses a special molecule to reduce the risk of colon cancer
In response to a ketogenic diet a special molecule is produced Strongly inhibits the growth of colorectal tumors. The discovery of this previously unknown metabolic signaling pathway could also significantly improve colorectal cancer prevention and treatment.
In a new study involving experts from University of Pennsylvania The possible benefits of different diets in the prevention and treatment of colon cancer examined. The results were published in the English-language journal Nature.
Link between colorectal cancer and diet
The team tested mice to see if different types of nutrition the inhibit the development and growth of colon cancer be able. To do this, they fed six groups of mice different forms of food containing different proportions of carbohydrates and fats.
The researchers then applied a standard chemical procedure that is normally colon tumors be evoked.
Ketogenic diet protects against colon tumors
The experts found that the forms of nutrition, which stronger keto and contained a fat to carbohydrate ratio of nine to one in most animals fed such diets prevent the development of colon tumors.
In addition, all mice that ate other diets, including low-fat and high-carbohydrate diets, were found to develop tumors.
Ketogenic diet slows tumor growth
Additionally, the researchers were able to identify another beneficial effect of ketogenic diets on colon cancer tumors. Even though the intestinal tumors in the animals had already started to grow, the ketogenic diet resulted in a treatment effect that caused the other growth and spread of tumors slowed down significantly.
What caused the tumor suppression?
The team found that those identified tumor suppression with a slower production of new epithelial cells linked by stem cells. Epithelial cells are cells that line the large intestine.
Role of beta-hydroxybutyrate
The team noted the slow growth of intestinal cells Beta-hydroxybutyrate (BHB) back. This natural molecule is normally found as part of a hunger response produced by the liver. In experiments with mice, the hormone was released as a result of the low-carb ketogenic diet, the experts report.
Beta-hydroxybutyrate is known to act as a alternative fuel source for important organs. The new study has now shown that BHB is not only a fuel source, but also a strong growth inhibitory signal it is, at least for the cells of the intestinal mucosa.
The researchers were able tumor suppressive effects of ketogenic diets play. To do this, the study animals were given BHB.
Why does BHB inhibit the growth of intestinal cells?
BHB was found to exert its anti-growth effect on intestinal cells by activating a surface receptor called Hcar2 unfolded. Hcar2 stimulates the expression of Hopx growth inhibitory gene.
Effect of BHB on human intestinal cells
Next were experiments with human intestinal cells accomplished. In these it was possible to demonstrate that BHB on the human versions of Hcar2 and Hopx die the same anti-growth effect on these cells.
The experts found that colon tumor cells that do not express these two genes did not respond to BHB treatment. According to the team, this indicates a possible benefit predictors For him efficacy of a treatment over there.
BHB as a standard ingredient in colorectal cancer treatments
“Our results suggest that this natural molecule, BHB, could one day become a standard part of colorectal cancer treatment and prevention.‘ reports the author of the study. dr levy mayan of the University of Pennsylvania in a press release.
“Clinical trials of BHB supplements are needed before a recommendation can be made for the use of BHB for prevention or treatment.‘ adds the author of the study dr Christoph Thaiss added, who is also in the University of Pennsylvania is working.
The team is already in the process of conducting a clinical trial with BHB colon cancer patients Act. In addition, the possible anticancer effects of BHB in other parts of the body and the effects of other molecules produced under ketogenic conditions will also be investigated. (What)
Author and source of information
This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.
- Oxana Dmitrieva-Posocco, Andrea C Wong, Patrick Lundgren, Aleksandra M Golos, Hélène C Descamps, et al: β-Hydroxybutyrate suppresses colorectal cancer; In: Nature (published April 27, 2022), Nature
- University of Pennsylvania School of Medicine: “Keto” Molecule May Help Prevent and Treat Colorectal Cancer, Study Suggests by Penn (Published 04/27/2022), University of Pennsylvania School of Medicine
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.