This diet changes the intestinal flora and slows down immune aging – healing practice

Diet influences the immune system through the intestinal flora

For the first time, a research team was able to show directly that a reduced calorie diet a positive effect on it immune system has and that this effect on that gut microbiome (intestinal flora) is mediated.

researchers of German Center for Diabetes Research could try how one Low-calorie diet changes the gut microbiome and how this change leads to Immune system aging slows down. The results of the research were recently presented in the journal “Microbiome”.

consequences of being overweight

About two billion people in the world are considered overweight. Being severely overweight (obese) in turn increases the risk of many serious diseases, including high blood pressure, heart attack, and type 2 diabetes.

Chronic inflammation due to obesity.

But being overweight also leads to increased Chronic inflamation arise in the body. The immune system responds by sending out additional memory T and B cells. in the long run it will be Immune system weakened by constant stress.

The immune system also weakens with age. This immune aging process is called immune senescence designated. This process is accelerated in people with obesity.

Interactions with the immune system

Studies have already shown that Calorie-restricted diets delay the development of metabolic diseases such as type 2 diabetes. and have a positive effect on the immune system.

However, until now it has remained unclear how this effect occurs and what role the microbiome plays in the gut. These interactions between Nutrition, microbiome, metabolism and immune system The working group of the German Center for Diabetes Research has now been able to clarify this.

How does a hypocaloric diet affect the intestinal flora?

The team looked at how a low-calorie diet with approx. 800 calories a day for eight weeks in the gut microbiome of an obese subject. In a further step, the researchers transferred the intestinal flora before and after the diet to a so-called gnotobiotic model in which no microorganisms were present.

“In this way we were able to determine the unique effects of the diet-influenced gut microbiome on metabolism and the immune system.”explains the author of the study Reiner Jumpertz de Schwartzenberg.

Positive effect on glucose metabolism and immune aging

By transferring the microbiome, the working group was able to show that the Improved glucose metabolism and she herself Reduced fat depositsif the intestinal flora was previously characterized by a hypocaloric diet.

Furthermore, the scientists showed that the Decreased number of certain memory T and B cells. “This indicates delayed immune senescence”emphasizes the first author of the study Julia Sbierski child.

“These results suggest that the positive effects of a low-calorie diet on metabolism and the immune system are mediated by the gut microbiome.”summarizes Sbierski-Kind.

limitation of results

However, the working group notes that the results of the Gut microbiome of an individual based. In further investigations, the findings must first be verified in a larger group. If confirmed, it would be extremely interesting for medical practice.

“A better understanding of the complex interplay between nutrition, the microbiome, and the immune system may lay the groundwork for the development of new microbiome-based therapeutic options for the Treatment of metabolic diseases and immune diseases. place”, emphasizes Jumpertz-von Schwartzenberg in conclusion. (verb)

Author and source of information

This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.


Graduate Editor (FH) Volker Blasek


  • German Center for Diabetes Research: A low-calorie diet changes the gut microbiome and immune aging (published: 04/22/2022),
  • Sbierski-Kind J, Spranger J, Jumpertz-von Schwartzenberg R et al.: Effects of calorie restriction on the gut microbiome are related to immune senescence; In: Microbiomes (2022). DOI: 10.1186/s40168-022-01249-4,

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.


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