High-fat diet promotes cancer by increasing nitric oxide levels
The consumption of a high fat diet is associated with an increase in nitric oxide in the Cancerous tumor microenvironment connected, who in turn tumor growth encourages A high-fat diet could have a significant impact on cancer progression.
In a recent study conducted by experts from Beckman Institute for Advanced Science and Technology examined the influence of diet on the microenvironment of cancerous tumors and tumor progression. The results can be read in the journal “ACS Central Science”.
Diet as a risk factor for cancer
According to experts, it has long been suspected that certain Feeding Habits the rise of Cancer can favor. The new study examined the effect of a high-fat diet on the signaling molecule nitric oxide, which is linked to inflammation and cancer development.
The research work was mice with breast cancer made, which were divided into two groups. One group of animals ate a high-fat diet in which 60 percent of calories consumed came from fat.
The second group of animals, on the contrary, consumed a low fat dietin which simply ten percent of the calories came from fat. The researchers compared the effects of these diets by measuring existing nitric oxide levels.
Changes in the microenvironment of tumors
“We seek to understand how subtle changes in the tumor microenvironment affect cancer progression at the molecular level‘ reports the author of the study. Anuj Yadav from the Beckman Institute for Advanced Science and Technology in a press release.
“Inflammation may play an important role in this environment. Certain inflammatory responses are triggered by highly processed foods that are high in calories and fat.Yadav continued.
To understand the links between food, inflammation and tumors at the molecular level, the team developed advanced probes that can visualize changes in the tumor microenvironment.
The highly sensitive molecular probe labeled BL660-NA should help establish the link between high-fat diet intake and nitric oxide levels at the molecular level.
A molecular probe is a group of atoms or molecules, which can be used to study the properties of neighboring molecules. To do this, the interactions between the probe and the structures of interest are measured, the researchers explain.
The probe developed for the new study is the first of its kind to be used to examine the Nitric Oxide Bioluminescence Imaging can be used in cancer. In this way, it was possible to determine how the mice’s diet affected their cancer, the team reports.
Increased nitric oxide in the tumor microenvironment
“As a result of the high-fat diet, we observed an increase in nitric oxide in the tumor microenvironment.‘ reports the author of the study. miguel reads.
Overall, according to experts, the study results indicate that a proinflammatory diet can increase nitric oxide production through macrophage recruitment and overexpression of inducible nitric oxide synthase. This could then drive tumor progression.
The tumor microenvironment is a very complex system that needs to be better understood. “Many factors can play a role in this, from diet to exercise, external factors that we don’t really consider, but should, when thinking about cancer treatments.“, adds leeward aggregate.
New research has shown a direct link between a high-fat diet, nitric oxide levels, and cancer development. Understanding this connection could have far-reaching implications for cancer diagnosis Y cancer therapy they have, depending on the team. (What)
Author and source of information
This text complies with the requirements of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.
- Anuj K Yadav, Michael C Lee, Melissa Y Lucero, Shengzhang Su, Christopher J Reinhardt, Jefferson Chan: Activity-based NIR bioluminescence probe enables discovery of diet-induced modulation of tumor microenvironment via nitric oxide; In: ACS Central Science (published May 16, 2022), ACS Central Science
- Beckman Institute for Advanced Science and Technology: Molecular probe links high-fat diet to nitric oxide levels and cancer development (published 05/16/2022), Beckman Institute for Advanced Science and Technology
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.