Vitamin E protects against weight gain even on a high-fat diet: healing practice

Vitamin E protection against obesity

a subspecies of Vitamin E It can potentially be used to treat obesity and weight problems, as even on a high-fat diet, suppressed weight gain. It also reduces the buildup of white adipose tissue around the kidneys and protects against liver damage from high-fat diets.

In a recent study involving Shibaura Institute of Technology in Japan it was found that the so-called tocotrienols (T3) are able to attenuate obesity by inhibiting the increase in body fat and serum cholesterol. The results of the study can be found in the journal Molecules.

dangers of obesity

Obesity threatens the health of many people around the world and at the same time promotes the development of various other diseases, such as diabetes Y cardiovascular diseases.

to get ahead over weight Y obesity To protect yourself, you should pay attention to a balanced diet on the one hand and sufficient exercise on the other. However, if this does not help reduce weight, effective drugs to treat obesity would be useful, the team explains.

However, so far only few substances or medications is known to be used to prevent or treat obesity and its dreaded aftermath You can contribute. One reason for this is that some of the mechanisms of the diseases caused by obesity are still relatively unclear, even among experts today.

Link between oxidation, obesity and Alzheimer’s

For example, there is evidence that obesity oxidative stress (oxidation) increases in the body. According to experts, this oxidative stress could be the reason why obesity favors the development of neurodegenerative diseases such as Alzheimer’s.

Consequently, it would be beneficial if potential drugs to treat obesity also included a strong antioxidant function the researchers add. The new study examined whether a subtype of vitamin E (tocotrienols or T3) is suitable here.

Effect of T3 studied

It was already known that T3 in mice, which have a high fat diet take one suppress weight gain possible, but the underlying mechanisms remain unclear.

To understand what mechanisms protect animals from weight gain, the team performed several experiments on mice fed either a high-fat diet or a high-fat diet along with T3. Additionally, there were control groups that ate a normal diet with or without T3.

It was found that animals fed a high-fat diet for a period of 13 weeks gained a lot of weight, compared to the control group. In contrast, mice fed a high-fat diet supplemented with T3 developed a significantly lower body weightaccording to experts.

Furthermore, it has been shown that T3 accumulation of white adipose tissue reduced around the kidneys and the liver that protected animals from harm caused by a high-fat diet.

T3 lowers low-density lipoprotein levels

The researchers were also able to observe that T3 contributed to increasing the content of low density lipoproteins (often as evil known as cholesterol) in the to lower the bloodwithout affecting the content of high-density lipoproteins (well cholesterol).

Prevention of obesity by T3

Overall, our results suggest that a higher intake of tocotrienols in the daily diet may be effective in preventing obesity.“, reported Professor Kōji Fukui from the Shibaura Institute of Technology in a press release.

As previous research has shown, obesity is on the rise cognitive dysfunction The researchers also investigated whether T3 helps reduce oxidative stress in the brain and prevents cognitive decline.

In so-called field trials, mice given only a high-fat diet appeared in an open field. much less to movewhat in general with anxiety or depression the researchers explain.

To understand why a high-fat diet has such an effect, the values ​​of biomarkers analyzed representing oxidative stress in the brain. furthermore, the Neurotrophic factor expression analyzed, reports the team. This is a special protein that plays a crucial role in the development of Neurons and cognitive functions theater plays.

However, the team was unable to identify any significant differences between the high-fat diet group and the control group that could explain why the high-fat diet affected the mice’s behavior in such a way. Also, T3 income had no effect here.

Potential as a drug

Although some of the effects of T3 in the body could not be explained, the study shows that Drug Development Potentialwhich could help in the fight against obesity.

We hope that our research will stimulate further study of anti-obesity compounds such as tocotrienols and related compounds. Our ultimate goal is to reduce the number of people suffering from obesity-related diseases.“, how that fukui teacher.

Never neglect exercise and a healthy diet

However, according to the experts, it is important to note that even if effective anti-obesity substances are identified in the future, balanced nutrition Y adequate physical activity they are an important first step towards a healthy body weight. (What)

Author and source of information

This text complies with the requirements of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.


  • Yugo Kato, Yoshinori Aoki, Chikako Kiyose, Koji Fukui: Tocotrienols attenuate white adipose tissue accumulation and improve serum cholesterol concentration in mice treated with a high-fat diet; In: Molecules (published on 03/28/2022), Molecules
  • Shibaura Institute of Technology: New Mice Study Sheds Light on Anti-Obesity Effects of Vitamin E (Published 04/18/2022), Shibaura Institute of Technology

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.


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