Vitamin K2 repairs nerve cells
vitamin k2 becomes a powerful due to its antioxidant effects neuroprotective potential granted, but so far it has not been clear through what mechanisms this is carried out. In a current study, so far unknown function of vitamin discovered, which might provide an explanation. The results of the corresponding study were published in the specialist journal “Nutrients”.
A Chinese research group led by Professor Zheng Zhiming of the Hefei Institute of Physical Sciences (HFIPS) chinese academy of sciences (CAS) has shown that vitamin K2 mitochondrial membrane potential regular and oxidative stress can degrade. This corrects mitochondrial dysfunctions and Prevent nerve cell damage.
They study the neuroprotective potential of vitamin K2
Vitamin K2 is present in higher concentrations animal products such as chicken, eggs, cheese, butter and quark, but also in herbal products such as fermented soybeans or sauerkraut.
The natural fat-soluble vitamin is due to its antioxidant effect also a neuroprotective potential He said the researchers have now verified his study. To do this, they first planted nerve cells 6-hydroxydopamine (6-OHDA) and then a treatment with vitamin K2.
6-OHDA is a neurotoxinleading to degeneration of dopaminergic neurons, leading to mitochondrial damage and nerve cell death the researchers explain.
For 6-OHDA was the “Reduced cell viability, decreased mitochondrial membrane potential, and increased accumulation of reactive oxygen species (ROS)”, reports the team. furthermore, the “Mitochondria-mediated apoptosis and abnormal mitochondrial fission and fusion” raised.
Nerve cell damage is significantly reduced.
However, vitamin K2 significantly suppressed the changes induced by 6-OHDA. This explains the first author. dr Tang Hengfang on the one hand with the fact that vitamin K2 assumes the role of main switch of apoptosis.
It does this by upregulating the expression of Bcl-2 and downregulating the expression of Bax, causing the mitochondrial membrane potential and the ROS values regulated and the oxidative stress be mitigated, so dr Spike.
On the other hand, vitamin K2 also maintains the normal functioning of the mitochondrial fusion, division, autophagy Y generation in a vertical position, allowing the normal operation of the mitochondrial quality control loop control and repair damaged mitochondria.
Mitochondrial damage removed
The results of the study indicate that vitamin K2 eliminate mitochondrial damage The researchers highlight that this effect is related to the involvement of vitamin K2 in the regulation of the mitochondrial quality control circuit.
In particular, keep mitochondrial quality control system and the Repair of mitochondrial dysfunction could be mediated by mitochondrial damage neuronal cell death counter.
Vitamin K2 usable against Alzheimer’s and Parkinson’s?
According to the researchers, vitamin K2 could help prevent and treat neurodegenerative diseases as Alzheimer’s Y Parkinson’s play a role as it repairs nerve cell damage. However, the study provides only early indications of such benefit.
To what extent, for example Dietary supplement with vitamin K2 may be useful remains to be clarified in future studies. must also be strong Federal Institute for Risk Assessment (BfR) an intake amount of a maximum of 25 µg of vitamin K2 per day not be exceeded.
In addition, it is noted that people taking anticoagulant medication should be warned before consuming food supplements containing vitamin K seek medical help should. (fp)
Author and source of information
This text corresponds to the requirements of the specialized medical literature, medical guidelines and current studies and has been reviewed by medical professionals.
- Hengfang Tang, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Peng Wang: Vitamin K2 modulates 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells through the mitochondrial quality control loop; In: Nutrients (published 4/4/2022), mdpi.com
- Hefei Institutes of Physical Sciences, Chinese Academy of Sciences: Scientists find vitamin K2 repairs nerve cells through mitochondrial quality control loop (published 04/14/2022), eurekalert.org
- Federal Institute for Risk Assessment (BfR): Proposals for maximum levels of vitamin K in foods, including food supplements (published March 15, 2021), bfr.bund.de
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.